Colorectal cancer is one of the most prevalent cancers worldwide, yet there is little information about using acupuncture to support people living with and beyond the disease. A philanthropically funded hospital-based outpatient acupuncture service facilitated long-term treatment for colorectal cancer survivors experiencing consequences of cancer treatment. In this two-part paper, the authors present four case studies illustrating how acupuncture affected a range of troublesome symptoms experienced by patients who had completed cancer treatments (surgery, radiotherapy and chemotherapy). This is part two of the article, and discusses two cases with multiple long-term consequences and comorbidities. The cases are enriched by comments written by the patients themselves and by their oncologist, providing a broader view of the effects of acupuncture treatment.