In many primitive societies, shamans or witch doctors often performed the dual roles of healer and intermediary between the worlds of men and spirits. With the support of ethnographic evidence, similarities between acu-moxibustion and shamanic practices are presented to suggest a possible origin of acu-moxibustion in the occult. Shamanic motives based on sacred-pain, spirit-letting via fenestration and fumigation are theorised for acu-moxibustion. Possible contributions from Daoist mysticism to Chinese medicine are proposed, particularly in the nomenclature of points. Tracing the origins of Chinese medicine and acu-moxibustion from a shamanic perspective can provide a novel appreciation of these arts.